Bile acid is an important component of bile and plays an important role in fat metabolism. Bile acids are mainly found in the enterohepatic circulatory system and play a protective role through recycling. Only a small portion of bile acids enters the peripheral circulation.
The driving force for promoting bile acid enterohepatic circulation is the liver cell transport system --- absorb bile acid and secrete it into bile, cholecystokinin-induced gallbladder contraction, small bowel advancing peristalsis, active transport of ileum mucosa, and Inflow.
At present, many experts in the animal medical field have researched this, and research has found that bile acids emulsify fat in animal bodies and expand the contact area with lipases; regulate the activity of pancreatic lipase and lipoprotein esterase to increase their hydrolytic metabolism; Transports fat in the intestine and promotes fat absorption. In addition, bile acids significantly reduce the catabolism of autologous fats by regulating the activity of hormone-sensitive lipases. To sum up, bile acid can save energy raw materials, improve energy utilization rate, improve growth performance and slaughter performance, and it is "positive energy" to save resources.
Active transport of bile acids to bile promotes the excretion of water and solutes. The secretion of cholesterol and lecithin is largely dependent on the secretion of bile acids. Bile acids and lecithin have important roles in maintaining cholesterol levels in bile.
Disruption of enterohepatic circulation may cause a decrease in bile acid / cholesterol and lecithin / cholesterol ratios in bile. At this time, the bile showed a state of cholesterol supersaturation. Cholesterol solubility and the formation of cholesterol gallstones are closely related to the size of circulating bile acid pools.
Bile acid helps to emulsify fat, enhances the lipolysis of the pancreas, and improves the solubility of lipids by forming mixed colloids to promote the absorption of lipids by the intestine. The important role of bile acids in fat absorption is confirmed by fat dysentery and symptoms that cause a decrease in intestinal bile salt concentration, such as bile congestion, cirrhosis, and taking bile acid-binding drugs.
1. Hepatobiliary disease
2. Gastrointestinal disorders
3． Other diseases that cause changes in bile acid metabolism