Augmentin 500mg is a short-term treatment for infections caused by Augmentin-sensitive bacteria. Bactericidal effect on many types of bacteria, including beta lactamase-producing bacteria resistant to ampicillin and amoxycillin ...
What is Augmentin 500mg?
Augmentin 500mg is an antibiotic with bactericidal action against many bacteria, including beta lactamase-producing bacteria resistant to ampicillin and amoxycillin. Augmentin medicine is a prescription antibiotic.
Augmentin drug structure 500mg
Country of Origin: Glaxo Wellcome Production, France.
Presentation format: Film-coated tablets.
Form of registration: Prescription drugs.
Package: Each pack of Augmentin tablets of 500mg contains 3 blisters, each pack has 4 tablets of Augmentin 500mg.
Active ingredient: Amoxicillin 500.00mg in the form of amoxicillin trihydrate, Clavulanic acid 62.50mg as potassium clavulanate in one package.
The pharmacology of the drug Augmentin 500mg
AUGMENTIN is an antibacterial drug.
Average pharmacokinetic parameters of amoxicillin and clavulanate potassium in normal adults after using AUGMENTIN Tablets and after using AUGMENTIN Powder for Oral Suspension and Chewable Tablets.
The concentration of Amoxicillin serum achieved with AUGMENTIN is similar to that produced by ingestion at the equivalent dose of amoxicillin alone. The time above the minimum inhibitory concentration of 1mcg / mL for amoxicillin has been shown to be similar every 12 hours and each 8-hour dosing regimen of AUGMENTIN in adults and children.
Dosages in the state of fasting or feeding have minimal effect on the pharmacokinetics of amoxicillin. Although AUGMENTIN can be given without regard to meals, the absorption of potassium clavulanate when taken with food is greater than the fasting state.
Both components in AUGMENTIN are high in protein; clavulanic acid binds about 25% to human serum and amoxicillin binds about 18%. Amoxicillin easily diffuses into most body tissues and fluids except the brain and spinal fluid.
Two hours after taking a suspension dose of AUGMENTIN 35 mg / kg for fasting children, an average concentration of 3 mcg / mL amoxicillin and 0.5 mcg / mL clavulanic acid was detected in the middle ear fluid.
Augmentin drug toxicity 500mg
Gastrointestinal disorders: Diarrhea, nausea, vomiting, indigestion are all side effects of Augmentin. The incidence of diarrhea when using Augmentin 250mg from 3 - 34% depending on the dose regime.
Candidiasis infection on skin and mucous membranes: Continuous use of Augmentin can lead to yeast or Candida yeast infections on the skin and mucosa.
Skin allergies: Skin reactions after taking Augmentin 500mg are relatively rare, including skin rash, itching, urticaria, erythema multiforme, and swelling in some parts (especially on face, tongue, throat).
Blood and lymphatic system disorders: Augmentin drugs have the ability to reduce the recovery of leukocytes (including neutrophils), thrombocytopenia, reversible granulocytopenia and hemolytic anemia.
The side effects of Augmentin 500mg on the nervous system include: dizziness, headache, or more rare signs such as reversible hyperactivity and seizures.
Immune system disorders: Undesirable effects of the Augmentin drug on the immune system are uncommon, but sometimes patients develop quite severe symptoms.
Augmentin drug interaction 500mg
Do not use at the same time as probenecid because this combination may increase and prolong the concentration of amoxycillin in the blood. However, clavulanic acid concentration was not affected. As with other broad-spectrum antibiotics, Augmentin should be used with great care in patients on anticoagulant therapy. Augmentin may reduce the effects of oral contraceptives and patients should be informed about this in advance.
*** Note: Information about the Augmentin 500mg article is for the purpose of sharing knowledge for reference only, patients are not allowed to use the drug themselves, all drug use information must be under the direction of a specialized physician. subjects.
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