What is Nitrofurantoin?
Nitrofurantoin is an antibiotic that fights bacteria in the body. The drug is used to treat urinary tract infections. Nitrofurantoin may also be used for purposes not listed in this medication guide.
Pharmacology and mechanism of action
Nitrofurantoin is an antibacterial, nitrofuran derivative, effective against many strains of gram-negative and gram-positive urinary tract bacteria. The mechanism of antimicrobial action of nitrofurantoin is unlike that of other antibacterial drugs.
Nitrofurantoin is reduced by bacterial flavoproteins to mediate the inactivation or modification of the bacterial ribosomal protein and some other macromolecules. Therefore, nitrofurantoin inhibits the biosynthesis of proteins, DNA, RNA and cell wall biosynthesis of bacteria. Nitrofurantoin has effect on many strains of E. coli, Enterococcus. Rare drug-sensitive bacteria become resistant during treatment. The minimum inhibitory concentration is about 32 micrograms / ml. The antibacterial activity of nitrofurantoin increases in acid pH urine.
Nitrofurantoin is quickly and completely absorbed from the gastrointestinal tract, the large crystalline form is absorbed and eliminated more slowly than the baby crystal form. With therapeutic doses, the antimicrobial concentration of nitrofurantoin in plasma is not achieved due to rapid elimination, plasma half-life is about 0.3 to 1 hour.
Nitrofurantoin is metabolized in the liver and tissues; about 40% is excreted unchanged in the urine and attains a high concentration in urine, about 200 micrograms / ml. The rate of excretion depends linearly on creatinine clearance, so for patients with reduced glomerular function, the effectiveness of treatment is reduced and the risk of poisoning increases. Nitrofurantoin brown color urine.
Drug information nitrofurantoin
International generic name: Nitrofurantoin.
ATC code: G04A C01.
Drug type: Urinary antibacterial nitrofuran drug.
Category: Medicines against urinary infections.
Drug form and content
Tablets: 50 mg, 100 mg; Capsules: 25 mg, 50 mg, 100 mg; mixed.
Solution: 25 mg / ml (300 ml).
Drug prices NITROFURANTOIN Comment at the end of the article to be informed of the price
Indications for the use of nitrofurantoin
Uncomplicated and chronic acute urinary tract infections caused by E. coli, Enterococcus, Staphylococcus saprophyticus, Staphylococcus aureus and susceptible strains of Klebsiella, Enterobacter.
Contraindications to the use of nitrofurantoin
The drug Nitrofurantoin is contraindicated to use for those who are allergic or hypersensitive to some of the ingredients in the drug or those who fall into the following cases:
Severe kidney disease, impaired kidney function
Have liver problems, impaired liver function
A history of jaundice
Urinary retention, less urination
Anemia, vitamin B deficiency, glucose deficiency - 6 - phosphate dehydrogenase
Inflammation of the optic nerve
Pregnant women are in the last 2 - 4 weeks of pregnancy
There are also a number of other objects that are not required to use. Patients wishing to use drugs, please consult your doctor before use, to avoid serious consequences later.
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