In 1936 the extremist system eliminated the improvements he had made for the Collegio dell'Opera Nazionale Ballila of Udine, guaranteeing they didn't commend the system however much they ought to. The next year he held an independent show at the Galleria Della Cometa in Rome and a while later ventured out to Paris, where he was significantly enlivened by crafted by the Impressionists. In 1938 Afro took part in the Venice Biennale, and during World War II he showed mosaic production at that city's Accademia di Belle Arti. During this period Afro likewise made the animation for the mosaics at the Palazzo dell'EUR in Rome, where his still lifes and pictures are unmistakably affected by Cubism. This was the first stage in quite a while shifting towards Abstraction. In the U.S. he came into contact with the Art Informel development, and his resulting compositions showed the impact of Arshile Gorky's work and Jackson Pollock's Action Painting.
In 1950 he had an independent show at the Catherine Viviano Gallery in New York, and in 1952 he joined the Gruppo degli Otto, with whom he displayed in 1956 at the Venice Biennale and proceeded to win the prize for best Italian painter. In 1958 he painted an enormous scope wall painting for the UNESCO central command in Paris. After two years he got the Guggenheim Award in New York and in 1971 the Presidente della Repubblica Prize at the Accademia di San Luca in Rome. He showed painting at the Florence Academy until 1973 and afterward moved to Zurich, where he passed on July 24, 1976.