If we are looking for a prescription for longevity in the 21st century and embracing a positive lifestyle and at the same time, desires to enjoyable life journey, should follow the basic principles regarding nutrition both physical engagement and mindfulness. It is well known that life expectancy has progressively increased in the last decades, but also at the same time there has been an increase in some common chronic diseases. Consequently, quality of life is not improved and thus it affects health. It is imperative that quantity and quality of life should be checked, both cannot move together. Thus, the first step is to modify this trend, i.e. to improve not only length of life but also wellness. The answer is simple, we must have proper nutrition by eating well to maintain our health and aspire to live better. Also, we must prevent these chronic diseases or, if already present, treat them better.