In January 2020, D’Amelio signed with United Talent Agency. In May, she and her sister announced a new podcast deal with Ramble Podcast Network, which will offer a behind-the-scenes look at their lives and specific topics on their minds.
D’Amelio’s acting career includes appearing on the Brat TV series Attaway General. On June 26, 2020, D’Amelio released her first single, “Be Happy”. As of August 28, 2021, the song has accumulated more than 86.1 million streams on Spotify.
On August 7, 2020, she signed a record deal with L.A. Reid’s label HitCo Entertainment. Forbes published a report in August 2020 revealing D’Amelio earned $2.9 million in the last year through June from her numerous sponsorship deals and merchandise, making her the third highest-earning TikTok star.
In December 2020, D’Amelio released her singles “One Whole Day” with Wiz Khalifa and “Roommates”, the latter of which was co-penned by Demi Lovato.
On July 16, 2021, D’Amelio began teasing a forthcoming single on Instagram, which was subsequently revealed to be titled “Psycho”. “Psycho”, featuring Kentucky rapper Rubi Rose was released on July 23, 2021.